C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/41 (2006.01) A61P 7/02 (2006.01)
Patent
CA 2595376
The present invention provides processes for the preparation of substituted naphthyl indole derivatives of formula (I) that can be used as inhibitors of plasminogen activator inhibitor- 1 (PAI-I) . In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyl tetrazole with a substituted naphthol.
La présente invention concerne des processus destinés à la préparation de dérivés de naphthylindole substitués qui peuvent être utilisés en tant qu'inhibiteurs, par ex., l'inhibiteur 1 de l'activateur du plasminogène, (PAI-I). Dans certains modes de réalisation, les processus impliquent des réactions qui comprennent une oxydation d'Oppenauer et/ou une synthèse d'indole de Fischer, un clivage d'éther méthylique ou un couplage d'un méthyltétrazole substitué avec un naphthol substitué.
Dragan Vladimir A.
Louise Helom Jean
Mcmahon Wayne G.
Potoski John Richard
Shi Xinxu
Torys Llp
Wyeth
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