Processes and intermediates for preparing...

Details Processes and intermediates for preparing... Processes and intermediates for preparing...

C - Chemistry, Metallurgy

07

D

C07D 275/04 (2006.01) C07D 295/26 (2006.01)

Patent

CA 2236940

Disclosed are processes for producing 3-(1- piperazinyl)-1,2-benzisothiazole of the formula: (see formula I) by reacting a compound of the formula: (see formula II) with piperazine at a temperature of 80-170°C. 3-(1- piperazinyl)-1,2-benzisothiazole is useful as an intermediate for producing 5-(2-(4-(1,2-benzisothiazol-3-yl)-1- piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one (ziprasidone) that has neuroleptic activity.

Procédés de préparation de 3-(1-pipérazinyl)-1,2-benzisothiazole ou de son sel pharmaceutiquement acceptable et nouveaux intermédiaires utilisés dans ce procédé. Le 3-(1-pipérazinyl)-1,2-benzisothiazole est un intermédiaire important utile à la préparation de ziprasidone.

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