Processes and intermediates for preparing anti-cancer compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 239/94 (2006.01) A61K 31/00 (2006.01) A61K 31/33 (2006.01) A61K 31/40 (2006.01) A61K 31/498 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 235/14 (2006.01) C07D 239/72 (2006.01) C07D 239/74 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 419/04 (2006.01) C07D 455/02 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 475/00 (2006.01) C07D 491/048 (2006.01) C07F 7/08 (2006.01) C07F 7/10 (

Patent

CA 2302965

The present invention relates to methods and intermediates for preparing compounds of the formula 1 Image and the pharmaceutically acceptable salts and solvates thereof, as well as structurally related compounds, wherein R1 and R2 are each independently selected from C1-C10 alkyl and C1-C10 alkoxy wherein said alkyl and alkoxy are optionally substituted by up to 2 substitutents independently selected from hydroxy and C1-C6 alkoxy; R15 is H, C1-C10 alkyl, or - (CH2)q(C6-C10 aryl), wherein q is an integer from 0 to 4. The foregoing compounds are useful in the treatment of hyperproliferative disorders, such as cancers, in mammals.

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