Processes and intermediates for preparing macrocycles

Details Processes and intermediates for preparing macrocycles Processes and intermediates for preparing macrocycles

C - Chemistry, Metallurgy

07

H

C07H 19/01 (2006.01) C07C 35/17 (2006.01) C07C 49/175 (2006.01) C07D 303/14 (2006.01) C07D 303/32 (2006.01) C07D 339/08 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07F 7/08 (2006.01) C07F 7/18 (2006.01) C07F 7/22 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2208131

Novel processes for the preparation of lactam- and lactone-containing macrocycles are provided. In preferred embodiments, rapamycin and demethoxyrapamycin are prepared by a convergent synthesis regime. Intermediates useful in the synthetic processes are also provided.

Nouveaux procédés de préparation de macrocycles contenant du lactame et de la lactone. Dans des modes de réalisation préférés, de la rapamycine et de la déméthoxyrapamycine sont préparées par un régime de synthèse convergente. Des intermédiaires utiles dans les processus de synthèse sont également décrits.

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