Processes for diagnosing and analysing tumours

Details Processes for diagnosing and analysing tumours Processes for diagnosing and analysing tumours

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2164728

The invention relates to a process for diagnosing and analysing tumours which is based on detecting the expression of certain variant exons of the CD44-gene. Detection may be carried out at the protein or nucleic acid level. In a preferred embodiment the expression is detected in biopsy material using exon-specific antibodies. Thus, for example, v6-expression is a suitable prognostic parameter for breast cancer, the expression of a transitional epitope which is coded by exons v7 and v8 serves to diagnose cervical cancer.

L'invention concerne un procédé pour le diagnostic et l'analyse de tumeurs, reposant sur la détermination de l'expression de variantes déterminées d'exon du gène CD44. Cette détermination peut se faire au niveau de la protéine ou de l'acide nucléique. Dans une forme de mise en oeuvre préférée, l'expression est déterminée dans un matériau de biopsie, au moyen d'anticorps spécifiques de l'exon. C'est ainsi, par exemple, que l'expression v6 convient comme paramètre pronostique pour le cancer du sein, l'expression d'un épitope de transition, qui est codé conjointement par les exons v7 et v8, pour le diagnostic du cancer du col de l'utérus.

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