Processes for forming a drug delivery device

Details Processes for forming a drug delivery device Processes for forming a drug delivery device

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/24 (2006.01) A61K 9/28 (2006.01) A61K 31/58 (2006.01) A61K 31/7072 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2484632

A drug delivery device can, in whole or in part, be formed by co-extruding a drug core and an outer tube. The outer tube may be permeable, semi-permeable, or impermeable to the drug. The drug core may include a polymer matrix which does not significantly affect the release rate of the drug. The outer tube, the polymer matrix of the drug core, or both may be bioerodible. The co- extruded product can be segmented into drug delivery devices. The devices may be left uncoated so that their respective ends are open, or the devices may be coated with, for example, a layer that is permeable to the drug, semi- permeable to the drug, or bioerodible.

L'invention porte sur un distributeur de médicaments qui est fabriqué, intégralement ou en partie, par co-extrusion d'un noyau de médicament et d'un tube externe. Le tube externe peut être perméable, semi-perméable, ou imperméable au médicament. Le noyau du médicament peut comprendre une matrice polymère qui n'a pas d'incidence significative sur le taux de libération du médicament. Le tube externe, la matrice polymère du noyau de médicament, ou les deux peuvent être bioérodables. Le produit co-extrudé peut être segmenté en distributeurs de médicaments. Ces dispositifs peuvent se présenter sans revêtement de manière que leurs extrémités respectives soient ouvertes, ou peuvent être revêtus, par exemple, d'une couche perméable au médicament, semi-perméable au médicament, ou bioérodable.

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