Processes for preparing 1,5-benzothiazepine derivatives

Details Processes for preparing 1,5-benzothiazepine derivatives Processes for preparing 1,5-benzothiazepine derivatives

C - Chemistry, Metallurgy

07

D

260/238.6

C07D 281/10 (2006.01)

Patent

CA 2015182

There is disclosed a process for preparing 1,5-benzothiaze- pine derivatives represented by the formula: Image (I) wherein R is a lower alkyl group, which comprises subjecting a propionic acid compound represented by the formula: Image (II) wherein R has the same meaning as defined above, to intramolecular ring closing reaction in the presence of a sulfonic acid compound represented by the formula: R1SO3H (III) wherein R1 represents a lower alkyl group or a sub- stituted or unsubstituted phenyl group.

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