C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/10 (2006.01) C07D 257/04 (2006.01) C07F 1/00 (2006.01) C07F 3/00 (2006.01) C07F 5/06 (2006.01) C07F 15/04 (2006.01)
Patent
CA 2191576
The present invention relates to processes for preparing 1-butyl-2-[2'-(2H- tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-indole-3-carboxylic acid and to intermediates useful in such processes. The present invention also relates to a process for deprotecting compounds containing a protected 2H-tetrazolyl group, which process comprises reacting a protected compound with a Lewis acid in the presence of a thiol.
L'invention concerne des procédés de préparation de l'acide 1-butyl-2-[2'-(2H-tétrazol-5-yl)biphényl-4-ylméthyl]-1H-indole-3-carboxylique et des intermédiaires utilisés dans de tels procédés. L'invention concerne également un procédé de déprotection de composés contenant un groupe 2H-tétrazolyle protégé, ce procédé consistant à faire réagir un composé protégé avec un acide de Lewis en présence d'un thiol.
Clark Robin Douglas
Fisher Lawrence Emerson
Flippin Lee Allen
Martin Michael Grant
Stabler Stephen Russell
Dennison Associates
Syntex (u.s.a.) Inc.
Syntex (u.s.a.) Llc.
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