Processes for preparing a substituted gamma-amino acid

Details Processes for preparing a substituted gamma-amino acid Processes for preparing a substituted gamma-amino acid

C - Chemistry, Metallurgy

07

C

C07C 227/04 (2006.01) A61K 31/195 (2006.01) A61P 29/00 (2006.01) C07C 229/08 (2006.01)

Patent

CA 2706381

The present invention is related to processes suitable for industrial synthesis of pregabalin from (i?)-(-)-3-(carbamoylmethyl) -5-methylhexanoic using sodium hypochlorite as described herein. In addition, the present invention is related to pregabalin which is substantially free of impurities and pharmaceutical compositions comprising pregabalin.

La présente invention concerne des procédés appropriés à la synthèse industrielle de prégabaline à partir d'acide (R)-(-)-3-(carbamoylméthyl)-5-méthylhexanoïque à l'aide d'hypochlorite de sodium, tels que décrits dans le présent document. En outre, la présente invention concerne une prégabaline qui est pratiquement exempte d'impuretés et des compositions pharmaceutiques contenant de la prégabaline.

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