Processes for preparing clarithromycin polymorphs

Details Processes for preparing clarithromycin polymorphs Processes for preparing clarithromycin polymorphs

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01) A61K 31/70 (2006.01) A61K 31/7048 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2397092

The present invention relates to processes for converting clarithromycin Form I to clarithromycin Form II, which include slurrying clarithromycin the Form I in water. The present invention also relates to processes for the preparation of clarithromycin Form II by converting erythromycin A to clarithromycin and thereafter converting clarithromycin Form I to clarithromycin Form II by slurrying.

L'invention concerne des procédés servant à transformer la clarithromycine de forme I en clarithromycine de forme II, qui comprennent l'étape consistant à mettre en suspension la clarithromycine de forme I dans de l'eau. L'invention concerne également des procédés de préparation de clarithromycine de forme II, qui comprennent les étapes consistant à transformer de l'érythromycine A en clarithromycine, et à transformer ensuite la clarithromycine de forme I en clarithromycine de forme II par une mise en suspension.

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