C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/08 (2006.01) A61K 31/7048 (2006.01) A61P 31/04 (2006.01) C07H 1/00 (2006.01)
Patent
CA 2395555
The present invention relates to processes for converting clarithromycin Form 0 to clarithromycin Form II, which include slurrying clarithromycin the Form 0 in water. The present invention also relates to processes for the preparation of clarithromycin Form II by converting erythromycin A to clarithromycin and thereafter converting clarithromycin Form 0 to clarithromycin Form II by slurrying. The present invention further relates to the novel clarithromycin polymorph Form IV, a process for its preparation, pharmaceutical compositions comprising the compound, and methods of using the compound as a therapeutic agent.
La présente invention concerne des procédés permettant de convertir une forme 0 de clarithromycine en forme II de clarithromycine. Ce procédé consiste à mettre en suspension la forme 0 de clarithromycine dans de l'eau. La présente invention concerne également des procédés de préparation de forme II de clarithromycine, consistant à convertir de l'érythromycine A en clarithromycine, puis à convertir la forme 0 de clarithromycine en forme II de clarithromycine, par mise en suspension. La présente invention concerne également la nouvelle forme polymorphique IV de clarithromycine, un procédé pour sa préparation, des compositions pharmaceutiques comprenant le composé, ainsi que des procédés d'utilisation du composé en tant qu'agent thérapeutique.
Avrutov Ilya
Borochovitz Ronen
Lifshitz Igor
Masarwa Basem
Schwartz Edi
Ridout & Maybee Llp
Teva Pharmaceutical Industries Ltd.
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