C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/16 (2006.01) C07D 487/04 (2006.01) C07F 5/04 (2006.01) C07F 7/08 (2006.01)
Patent
CA 2749483
The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-di]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are use-ful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloprolif-erative disorders, and other diseases.
La présente invention concerne des procédés de préparation de pyrrolo[2,3-di]pyrimidines chirales substituées par un pyrazolyle de formule III, et des composés intermédiaires synthétiques apparentés. Les pyrrolo[2,3-di]pyrimidines chirales substituées par un pyrazolyle sont utiles comme inhibiteurs de la famille des Janus kinase des protéines tyrosine kinase (JAK) pour traiter des maladies inflammatoires, des troubles myoléprolifératifs, et d'autres maladies.
Li Mei
Lin Qiyan
Liu Pingli
Meloni David
Metcalf Brian W.
Borden Ladner Gervais Llp
Incyte Corporation
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