Processes for preparing sildenafil

Details Processes for preparing sildenafil Processes for preparing sildenafil

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) C07D 231/40 (2006.01)

Patent

CA 2235642

Sildenafil, a known pharmaceutical chemical useful in treatment of male sexual dysfunction, is prepared by processes in which the final chemical intermiadiate is of significantly lower basicity than sildenafil itself, so that sildenafil can be extracted in substantially pure form from the organic reaction mixture in which it is made by adding an aqueous medium of appropriately chosen acidic pH and causing phase shift of the sildenafil to occur selectively into the aqueous phase.

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