Processes for producing 2-substituted benzo[b]thiophene

Details Processes for producing 2-substituted benzo[b]thiophene Processes for producing 2-substituted benzo[b]thiophene

C - Chemistry, Metallurgy

07

D

C07D 333/70 (2006.01) C07C 319/14 (2006.01) C07C 319/18 (2006.01) C07C 323/22 (2006.01) C07D 333/56 (2006.01)

Patent

CA 2079073

A 2-alkylthiobenzaldehyde of general formula (I) is reacted with a halo compound of general formula (II) to produce a 2-substituted benzo[b]thiophene of general formula (III). Image (I) wherein R1 means an alkyl group of 1 to 4 carbon atoms. X1CH2Y (II) wherein X1 means Cl or Br; Y means -CO2H, -CO2R, -COR2, -CONH2 or -CN; R2 means an alkyl group of 1 to 4 carbon atoms. Image (III) wherein Y is as defined above. The process of this invention is of great economic and industrial value, for 2-acetylbenzo[b]thiophene and 2-benzo[b]thiophenecarboxylic acid, which are important intermediates for drugs and agricultural chemicals among others, can be obtained in a simple manner, easily and in high yield.

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