Processes for producing phenoxy propionic acid derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 241/44 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2257204

A process for producing D(+)-2-[4-(6-chloro-2-quinoxalyloxy)phenoxy]propionic acid, which comprises reacting an alkali metal salt of 4-(6-chloro-2-quinoxalyloxy)phenol with an alkali metal salt of L-2- chloropropionic acid in an aromatic hydrocarbon solvent in the presence of an aprotic polar solvent to obtain an alkali metal salt of D(+)-2- [4-(6-chloro-2-quinoxalyloxy)phenoxy]propionic acid, and treating it with an acid.

Cette invention concerne un procédé permettant de produire de l'acide D(+)-2-[4-(6-chloro-2-quinoxalyloxy)phénoxy]propionique, lequel procédé consiste à faire réagir un sel de métal alcalin de 4-(6-chloro-2-quinoxalyloxy)phénol avec un sel de métal alcalin d'acide L-2-chloropropionique. Cette réaction, qui se fait dans un solvant hydrocarbure aromatique et en présence d'un solvant polaire aprotique, permet d'obtenir un sel de métal alcalin d'acide D(+)-2-[4-(6-chloro-2-quinoxalyloxy)phénoxy]propionique, lequel est ensuite traité à l'aide d'un acide.

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