C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/15 (2006.01) A61K 35/58 (2006.01) A61K 38/57 (2006.01) A61L 33/00 (2006.01) C07K 1/14 (2006.01) C07K 14/46 (2006.01) C07K 14/78 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2045692
(54) Title: PROCESSING FOR PRODUCING POLYPEPTIDE INHIBITORS OF PLATELET ACTIVATION AND METH- ODS, COMBINATIONS AND COMPOSITIONS USING THEM (57) Abstract The present invention relates to polypeptide inhibitors of platelet activation and derivatives thereof, purified from the ven- om of the North American Water Moccasin and to methods for their purification. This invention also relates to DNA sequences and recombinant DNA molecules which code for these polypeptide inhibitors of platelet activation. And this invention relates to recombinant DNA molecules which code for fusion proteins comprising both a polypeptide inhibitor of platelet activation and a conventional anti-thrombin polypeptide. This invention also relates to pharmaceutically acceptable compositions and methods characterized by at least one of these natural or recombinant inhibitors of platelet activation, alone or in combination with con- ventional anti-thrombin compounds. The compositions, combinations and methods of this invention are particularly useful in the treatment of thrombotic diseases.
Chao Betty H.
Jakubowski Joseph A.
Maraganore John M.
Bereskin & Parr
Biogen Inc.
The Trustees Of Boston University
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