Processes for recovering stabilized formulations of trimers...

Details Processes for recovering stabilized formulations of trimers... Processes for recovering stabilized formulations of trimers...

C - Chemistry, Metallurgy

07

K

C07K 14/15 (2006.01) A61K 39/21 (2006.01) A61P 31/18 (2006.01) A61P 37/04 (2006.01) C07K 1/00 (2006.01) C07K 1/16 (2006.01) C07K 14/16 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2655929

This invention provides processes of purifying and recovering trimers of a retroviral envelope (Env) protein from a preparation comprising trimers of the retroviral Env protein and high molecular weight aggregates thereof. Non-ionic detergent is used in the processes to obtain a purified trimer product, which is separated from aggregates. The process further comprises treating the preparation with a non-ionic detergent so as to thereby convert the high molecular weight aggregates into trimers, and purifying and recovering the trimers from the preparation so treated.

La présente invention concerne des procédés de purification et de récupération de trimères d'une protéine d'enveloppe (Env) rétrovirale à partir d'une préparation comprenant des trimères de la protéine Env rétrovirale et ses agrégats de masse moléculaire élevée. Un détergent nonionique est employé dans ces procédés pour obtenir un produit trimère purifié, qui est ensuite séparé des agrégats. Le procédé comprend en outre le traitement de la préparation à l'aide d'un détergent nonionique afin de convertir les agrégats de masse moléculaire élevée en trimères, et la purification suivie de la récupération des trimères de la préparation ainsi traitée.

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