Processes for the manufacture of novel glucose derivatives

Details Processes for the manufacture of novel glucose derivatives Processes for the manufacture of novel glucose derivatives

C - Chemistry, Metallurgy

07

C

530/9

C07C 103/52 (1980.01)

Patent

CA 1183528

- 36 - Abstract The invention relates to processes for the manufac- ture of muramyl peptide derivatives of the formula I (I) Image characterised in that at least one of the radicals R7, R9 and R13 represents lower alkyl, whilst the others represent hydrogen. The remaining substituents of the formula I are defined in claim 1. These compounds possess excellent immunomodulatory activity whilst, at the same time, especially when the substituent R7 represents lower alkyl, the pyrogenic side effect is greatly reduced as com- pared with the corresponding NH-compounds. They can there- fore be used in the form of pharmaceutical preparations. In addition, the compounds according to the invention are used for the manufacture of the conjugates with antigens described in European Patent Application No. 79100513.5 and in Canadian Patent Application No. 321 992.

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