Processes for the preparation of 1,2,4-oxadiazole benzoic acids

Details Processes for the preparation of 1,2,4-oxadiazole benzoic acids Processes for the preparation of 1,2,4-oxadiazole benzoic acids

C - Chemistry, Metallurgy

07

D

C07D 271/06 (2006.01)

Patent

CA 2662749

Provided herein are processes for the preparation of compounds useful for the treatment, prevention or management of diseases associated with a nonsense mutation. More specifically, provided herein are processes for the synthesis of 1,2,4-oxadiazoles. In particular, provided herein are processes useful for the preparation of 3-[5-(2-fluorophenyl)- [1,2,4]oxadiazol-3-yl]-benzoic acid.

La présente invention concerne des procédés de préparation de composés utilisables pour le traitement, la prévention ou la gestion de maladies associées à une mutation non-sens. L'invention concerne plus spécifiquement des procédés de synthèse des 1,2,4-oxadiazoles. En particulier, l'invention concerne des procédés utilisables pour la préparation de l'acide 3-[5-(2-fluorophényl)-[1,2,4]oxadiazol-3-yl]-benzoïque.

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