C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01)
Patent
CA 2612612
The present invention provides new processes for the preparation of unsubstituted and substituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline- l,3-dione compounds which are useful, for example, for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF- .alpha.. The invention can provide improved and/or efficient processes for the commercial production of unsubstituted and substituted 4-amino-2-(2,6- dioxopiperidin-3-yl)isoindoline-l,3-dione compounds, including, but not limited to, unsubstituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3- dione.
La présente invention concerne des procédés pour l'élaboration de composés 4-amino-2-(2,6-dioxopipéridin-3-yl)isoindoline-l,3-dioniques, éventuellement substitués. Ces composés conviennent particulièrement à la prévention ou au traitement d'affections ou d'états en lien ave un niveau anormalement élevé d'actifité du TNF-a. L'invention concerne également des procédés améliorés et/ou efficaces de production commerciale de composés 4-amino-2-(2,6-dioxopipéridin-3-yl)isoindoline-l,3-dioniques substitués et non substitués, et notamment de 4-amino-2-(2,6-dioxopipéridin-3-yl)isoindoline-l,3-dione non substitué.
Chen Roger
Ge Chuansheng
Muller George W.
Saindane Manohar T.
Celgene Corporation
Smart & Biggar
LandOfFree
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