Processes for the preparation of...

Details Processes for the preparation of... Processes for the preparation of...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01)

Patent

CA 2521348

The invention relates to processes for preparing compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R6 R11, R13 R14 R15, R16, R17, k, I, and m are as defined herein. The present invention also relates to intermediates represented by the formula (3a) wherin R4, and R5 are independently selected from hydrogen and C1- C6alkyl; each R13, R14, R15 and R16 is independently selected from hydrogen, C1-C6alkyl and CH2OH, R17 and R18 are independently C1-C6 alkyl, and k and I are independently an integer from 1 to 3, as well as to a process for preparing these intermediates.

L'invention se rapporte à des procédés de préparation de composés de la formule (1) et à leurs sels pharmaceutiquement acceptables, à leurs promédicaments et solvates; formule dans laquelle R?1¿, R?3¿, R?4¿, R?6¿, R?11¿, R?13¿, R?14¿, R?15¿, R?16¿, R?17¿, k, l, et m sont tels que definis. La présente invention concerne également des intermédiaires représentés par la formule (3a), dans laquelle R?4¿ et R?5¿ sont indépendamment choisis entre hydrogène et C¿1?-C¿6? alkyle; R?13¿, R?14¿, R?15¿ et R?16¿ sont chacun indépendamment choisis entre hydrogène, C¿1?-C¿6? alkyle et CH¿2?OH, R?17¿ et R?18¿ représentent indépendamment C¿1?-C¿6? alkyle, et k et l représentent indépendamment un entier compris entre 1 et 3; et un procédé de préparation de ces intermédiaires.

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