Processes for the preparation of 3',4'-dideoxykanamycin b

Details Processes for the preparation of 3',4'-dideoxykanamycin b Processes for the preparation of 3',4'-dideoxykanamycin b

C - Chemistry, Metallurgy

07

H

260/230.5

C07H 15/22 (2006.01)

Patent

CA 1076568

TITLE OF INVENTION: New Processes for the Preparation of 3',4'- Dideoxykanamycin B ABSTRACT OF THE DISCLOSURE: New routes are provided for the synthesis of 3',4'-dideoxykanamycin B which is effective in inhibiting kanamycin-resistant organisms from kanamycin B through new intermediate, of which a fundamental process comprises a new reaction of a 3',4'-epoxy derivative of amino- and hydroxyl-protected kanamycin B with a xanthate to form a corresponding 3',4'-dideoxy-3'-eno derivative followed by: removal of the amino- and hydroxyl-protecting groups thereof and by hydrogenation of the resulting 3',4'- dideoxy-3'-eno-kanamycin B. A 3',4'-episulfide deriv- ative corresponding to the 3',4'-epoxy derivative which is formed as second product in the reaction of 3',4'- epoxy derivative with xanthate is also used as intermediate for the preparation of 3',4'-dideoxykanamycin B. - 1 -

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