Processes for the preparation of modafinil and analogs thereof

Details Processes for the preparation of modafinil and analogs thereof Processes for the preparation of modafinil and analogs thereof

C - Chemistry, Metallurgy

07

C

C07C 315/02 (2006.01) C07C 317/44 (2006.01) C07C 323/52 (2006.01)

Patent

CA 2632722

The present invention generally relates to an improved process for preparing modafinil and analogs thereof. The process minimizes impurities and improves the overall yield by oxidizing a modafinil intermediate compound in a reaction mixture including an alcohol and an organic acid at a ratio of from about 1:1 to about 80:1 (by volume).

La présente invention concerne généralement un procédé amélioré pour préparer le modafinil et des analogues de celui-ci. Le procédé réduit au minimum les impuretés et améliore le rendement total en oxydant un composé intermédiaire de modafinil dans un mélange de réaction comprenant un alcool et un acide organique à un rapport d'environ 1:1 à environ 80:1 (en volume).

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