C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/82 (2006.01) C07D 213/56 (2006.01)
Patent
CA 2755297
The present invention relates to processes for producing a diaryl amine compound of the formula (I); or a salt thereof, said process comprising the step of coupling a compound of formula (II) with an amine of formula (III) in the presence of an alkali metal salt or a transition metal catalyst, (see formula I) Ar1-X (II) Ar2-NH-Y (III) wherein: Ar1 and Ar2 are independently Q; wherein each Q is an aryl or heteroaryl ring system optionally fused to a saturated or unsaturated 5-8 membered ring having 0-4 heteroatoms; wherein Q is optionally substituted as defined in claim 1, wherein: X is a leaving group; and Y is -C(O)-O-Z; and Z is selected from C1-C6 aliphatic, benzyl, Fmoc, -SO2R' and Q, provided that Q is not substituted with X or alkyne, wherein R' is hydrogen, an aliphatic, a carbocyclic or a heterocyclic. In one embodiment, there is provided a compound of formula (A) or formula (B): (see formula A) (see formula B) wherein: each of X1, X2, X3, and X4 is independently fluoro or chloro; and R is H or methyl.
Oliver-Shaffer Patricia Ann
Snoonian John R.
Smart & Biggar
Vertex Pharmaceuticals Incorporated
LandOfFree
Processes for the preparation of n-heteroaryl-n-aryl-amines... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Processes for the preparation of n-heteroaryl-n-aryl-amines..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Processes for the preparation of n-heteroaryl-n-aryl-amines... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1932583