C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) C07D 209/46 (2006.01)
Patent
CA 2579291
The present invention concerns new processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines which are useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF.alpha.. The invention provides processes for the commercial production of substituted 2-(2,6-dioxopiperidin-3-yl)-1- oxoisoindolines including, but not limited to, the therapeutically active 3-(4- amino-1-oxoisoindolin-2-yl) piperidine-2,6-dione.
La présente invention concerne de nouveaux procédés de préparation de 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines substituées qui sont utiles pour prévenir ou pour traiter des maladies ou des troubles relatifs à un niveau anormalement élevé d'activité de TNFa. L'invention présente des procédés de production commerciale de 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines substituées contenant, de façon non exhaustive, la 3-(4-amino-1-oxoisoindolin-2-yl) piperidine-2,6-dione à activité thérapeutique.
Chen Roger
Ge Chuansheng
Muller George W.
Saindane Manohar Tukaram
Celgene Corporation
Smart & Biggar
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