Processes for the preparation of tomoxetine

Details Processes for the preparation of tomoxetine Processes for the preparation of tomoxetine

C - Chemistry, Metallurgy

07

C

C07C 213/06 (2006.01) C07C 217/48 (2006.01)

Patent

CA 2561015

Provided are processes for preparing tomoxetine comprising reacting N~methyl-3- hydroxy-3-phenylpropylamine with dimethylsulfoxide (DMSO) and 2-~fluorotoluene in the presence of an alkali base to form tomoxetine. Also provided is the conversion of said tomoxetine into atomoxetine or a pharmaceutically acceptable salt thereof.

L~invention concerne des procédés de préparation de la tomoxétine consistant à faire réagir la N-méthyl-3-hydroxy-3-phénylpropylamine avec le diméthylsulfoxyde (DMSO) et le 2-fluorotoluène en présence d'une base alcali pour former la tomoxétine. L~invention concerne en outre la conversion de ladite tomoxétine sous la forme de l~atomoxétine ou d~un sel de celle-ci acceptable sur le plan pharmaceutique.

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