Processes for the production of hcmv glycoproteins,...

Details Processes for the production of hcmv glycoproteins,... Processes for the production of hcmv glycoproteins,...

C - Chemistry, Metallurgy

12

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167/130, 167/140

C12N 15/38 (2006.01) A61K 39/245 (2006.01) A61K 39/42 (2006.01) C07K 14/045 (2006.01) C07K 16/08 (2006.01) C12N 15/86 (2006.01) C12P 21/08 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1335429

HCMV glycoproteins B and H have been identified. The gB protein is encoded by DNA in the HindIII F fragment of the HCMV genome lying between 1378 and 4095 bases from the F/D boundary. The gH protein is encoded by DNA in the HindIII L fragment lying between 228 and 2456 bases from the L/D boundary. The genes have been incorporated in recombinant vaccinia vectors and expressed in host animals to raise HCMV-neutralising antibody, thereby indicating vaccine potential. The glycoproteins can also be used in a variety of different ways, as vaccines or in the production, purification or detection of HCMV antibody.

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