Processes for the synthesis of imines, aldehydes, and...

C - Chemistry – Metallurgy – 07 – D

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C07D 213/44 (2006.01) C07C 209/60 (2006.01) C07C 211/48 (2006.01) C07D 213/38 (2006.01) C07D 213/48 (2006.01) C07D 213/53 (2006.01)

Patent

CA 2086553

2086553 9202507 PCTABS00010 Imines are synthesized by the hydrogenation of pyridinecarbonitriles with amines in the presence of a rhodium-loaded catalyst. The resulting imines are stable and may be transiminated and then hydrogenated to form selected secondary amine products or may be hydrolyzed to aldehydes. Further, a very useful class of unsymmetrical secondary amines represented by the formula RCH2NHAr (in which R is not aliphatic and Ar is aromatic and not attached to R), which has heretofore been accessible only with some difficulty, can be synthesized by processes herein disclosed utilizing the reductive intermolecular coupling of nitriles and primary aromatic amines.

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