C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/088 (2006.01) C07C 27/00 (2006.01) C07D 295/073 (2006.01) C07D 295/096 (2006.01)
Patent
CA 2724887
The present invention provides a compound of formula (IV) wherein R is Cl, Br, NO2, OH or OR', and R' is alkyl, and its use in the synthesis of levocetirizine, including its use in the synthesis of (-)-1-[(4-chlorophenyl)-phenyl methyl] piperazine, an intermediate useful in the synthesis of levocetirizine. The present invention also provides compounds (II) and (III) which are useful in the synthesis of compound (IV).
La présente invention porte sur un composé de formule (IV) dans laquelle R représente Cl, Br, NO2, OH ou OR', et R' représente alkyle, et sur son utilisation dans la synthèse de lévocétirizine, comprenant son utilisation dans la synthèse de la (-)-1-[(4-chlorophényl)-phénylméthyl]pipérazine, un intermédiaire utile dans la synthèse de la lévocétirizine. La présente invention porte également sur des composés (II) et (III) qui sont utiles dans la synthèse du composé (IV).
Chikhalikar Sandip Vasant
Curtis Philip Anthony
Ghagare Maruti
Kankan Rajendra Narayanrao
Rao Dharmaraj Ramachandra
Cipla Limited
Sim & Mcburney
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