Processes for the treatment of vascular disease

Details Processes for the treatment of vascular disease Processes for the treatment of vascular disease

C - Chemistry, Metallurgy

12

N

195/39.1, 195/1.

C12N 9/64 (2006.01) A61K 38/46 (2006.01) C07K 14/745 (2006.01) C12N 5/10 (2006.01) C12N 9/72 (2006.01) C12N 15/09 (2006.01)

Patent

CA 1340942

Disclosed herein are improved processes for preparing variant human t-PA proteins exhibiting improved pharmacokinetic properties relative to natural t-PA. One such illustrated variant, devoid of amino acids corresponding to amino acids 1 through 44 of natural t-PA, is shown to exhibit a plasma half-life of greater than about 15 times the plasma half-life of natural t-PA, as well as a clearance rate of less than about 1/10 the clearance rate of natural t-PA. Also disclosed are improved processes for treating vascular disease employing pharmaceutical compositions which incorporate therapeutically effective amounts of such t-PA variants with pharmaceutically acceptable diluents or excipients.

570881

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