A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/10 (2006.01) B01F 3/12 (2006.01) A61K 31/216 (2006.01) A61K 31/573 (2006.01) A61K 38/13 (2006.01)
Patent
CA 2335472
Submicron particles of water-insoluble compounds, particularly drugs, are prepared by simultaneously stabilizing microparticulate suspensions of same with surface modifier molecules by rapid expansion into an aqueous medium from a compressed solution of the compound and surface modifiers in a liquefied gas and optionally homogenizing the aqueous suspension thus formed with a high pressure homogenizer.
L'invention concerne la préparation de particules submicroniques de composés insolubles dans l'eau, notamment de médicaments, qui comporte les étapes consistant à stabiliser simultanément des suspensions de microparticules de ceux-ci avec des molécules de modificateur de surface par expansion rapide dans un milieu aqueux, à partir d'une solution comprimée du composé et de modificateurs de surface dans un gaz liquéfié; et éventuellement homogénéiser la suspension aqueuse ainsi formée à l'aide d'un homogénéisateur haute pression.
Gudinas Anthony
Henriksen Inge B.
Krukonis Val
Mishra Awadhesh K.
Pace Gary W.
Ridout & Maybee Llp
Rtp Pharma Inc.
Skyepharma Canada Inc.
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