A - Human Necessities – 61 – F
Patent
A - Human Necessities
61
F
A61F 2/02 (2006.01) A61K 35/12 (2006.01) C08J 9/28 (2006.01) C12N 5/00 (2006.01) C12N 11/08 (2006.01)
Patent
CA 2627667
This invention relates to a method for fabricating large scaffolds in a variety of shapes with an organized pore structure. The pore structure is organized such that pores are generally aligned perpendicular to the edges of the scaffold, regardless of-the particular macroscopic scaffold shape. Specifically, a freeze-drying based fabrication method for creating large, polymeric porous scaffolds for tissue engineering applications, with an organized pore structure of columnar pores extending from the scaffold periphery into the main mass of the scaffold.
La présente invention a pour objet une méthode de fabrication de grands échafaudages sous différentes formes montrant une structure organisée des pores. La structure des pores est organisée de façon à ce que lesdits pores soient alignés généralement perpendiculaires aux bords de l'échafaudage, quelle que soit la forme macroscopique particulière de l'échafaudage. En particulier, une méthode de fabrication à base de lyophilisation permet de créer de grands échafaudages de polymères poreux pour des applications en ingénierie tissulaire, ayant une structure de pores organisée en colonnes de pores s'étendant de la périphérie de l'échafaudage à la masse principale de l'échafaudage.
Harley Brendan
Reddy Harry K.
Yannas Ioannis V.
Zagorski Christpher L.
Massachusetts Institute Of Technology
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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