Processing of slpi by chymase

Details Processing of slpi by chymase Processing of slpi by chymase

G - Physics

01

N

G01N 33/53 (2006.01)

Patent

CA 2636774

It is now discovered that human chymase cleaves human SLPI at a specific site and that this cleavage can be used as an indicator of chymase activity. The present invention provides methods of diagnosing a chymase-associated disease or evaluating the efficiency of a treatment of a chymase-associated disease in a human subject by measuring SLPI processing, as well as other related methods and compositions.

Dans l'invention, on a découvert que la chymase humaine clive l'inhibiteur sécrétoire de la protéase du leucocyte (SLPI) humain, sur un site spécifique; et que ce clivage peut être utilisé pour indiquer l'activité de la chymase. L'invention concerne également des méthodes de diagnostic d'une maladie associée à la chymase, ou des méthodes d'évaluation de l'efficacité d'un traitement d'une maladie associée à la chymase, chez un patient humain, par mesure du traitement de SLPI. L'invention concerne encore d'autres méthodes et compositions associées.

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