Procyanidin oligomers inhibiting matrix metalloproteinases...

Details Procyanidin oligomers inhibiting matrix metalloproteinases... Procyanidin oligomers inhibiting matrix metalloproteinases...

A - Human Necessities

61

K

A61K 31/353 (2006.01) A61K 31/35 (2006.01)

Patent

CA 2379489

The present invention provides procyanidin oligomers with significant biological activity against matrix metalloproteinase (MMP). The procyanidin oligomers can be isolated from the genus Ulmus and other plants and comprise trimeric through dodecameric procyanidin oligomers of flavan-3-ol monomer units. The present invention encompasses methods of using the procyanidin oligomer in treating tumor metastasis or invasion, rheumatoid arthritis, diabetes, corneal, epidermal, and gastric ulceration, skin wrinkling, periodontitis, osteoporosis; and in the promotion of wound and burn healing and other related maladies in which uncontrolled high levels of MMP are thought to play an important role in the malady progress.

La présente invention concerne des oligomères de procyanidines présentant une activité biologique important contre les métalloprotéases matrices. Ces oligomères de procyanidines peuvent être isolés à partir du genre Ulmus et d'autres plantes. Ils comprennent des oligomères de procyanidines trimères à dodécamères d'unités monomères flavan-3-ol. L'invention concerne également des modes d'utilisation d'un tel oligomère de procyanidine pour le traitement de la métastase ou l'invasion tumorale, de la polyarthrite rhumatoïde, du diabète, des ulcères de la cornée, de l'épiderme et de l'estomac, les rides, la périondontite, la résorption osseuse, et pour favoriser la guérison des blessures et d'autres affections connexes où les niveaux élevés incontrôlés de métalloprotéases matrices sont susceptibles de jouer un rôle important pour la progression de la maladie.

Affiliated with

Also associated with

Rating

Procyanidin oligomers inhibiting matrix metalloproteinases... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Procyanidin oligomers inhibiting matrix metalloproteinases..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Procyanidin oligomers inhibiting matrix metalloproteinases... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1878395