Prodrug activation using catalytic antibodies

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 15/24 (2006.01) C07H 15/252 (2006.01) C07K 2/00 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2375072

The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compounds and methods of converting such compounds to active therapeutic agents using molecules having aldolase activity.

La présente invention concerne un composé qui comprend un agent thérapeutique actif attaché à un groupe fonctionnel de blocage sensible à l'action des molécules possédant une activité catalytique rétro-aldol et rétro-Michael, des procédés de fabrication de ces composés et des procédés de transformation de ces composés en des agents thérapeutiques actifs au moyen de molécules ayant une activité d'aldolase élevée.

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