Prodrug compositions and drug delivery methods using...

A - Human Necessities – 61 – K

Patent

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A61K 47/48 (2006.01) A61K 31/71 (1995.01)

Patent

CA 2253204

The present invention provides prodrug and multi-prodrug complexes comprising drugs specifically bound to synthetic receptors in such a manner that active drug becomes available only in the presence of a targeted pathophysiologic receptor. Methods for preparation and use of these prodrug complexes in drug delivery systems are also provided.

La présente invention concerne des complexes de promédicaments et de multi-promédicaments comprenant des médicaments qui se fixent de manière spécifique sur des récepteurs synthétiques de telle manière que le médicament actif devient disponible uniquement en présence d'un récepteur pathophysiologique ciblé. Des procédés de préparation et d'utilisation de ces complexes de promédicaments dans des systèmes d'administration de médicaments sont également décrits.

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