C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 47/48 (2006.01) C07K 5/10 (2006.01)
Patent
CA 2354766
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme trouase. Also disclosed are processes for making the prodrug compounds.
La présente invention concerne un promédicament constituant une forme modifiée d'un agent thérapeutique et comprenant un agent thérapeutique, un oligopeptide, un groupe de stabilisation et, en option, un groupe de liaison. Ce promédicament est clivable par l'enzyme trouase. L'invention concerne également des procédés de fabrication des composés à base du promédicament.
Dubois Vincent
Fernandez Anne-Marie
Gangwar Sanjeev
Lewis Evan
Lobl Thomas J.
Coulter Pharmaceutical Inc.
Gowling Lafleur Henderson Llp
Medarex Inc.
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