Prodrug compounds with isoleucine

Details Prodrug compounds with isoleucine Prodrug compounds with isoleucine

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2413149

The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by an enzyme associated with the target cell. Methods of making and using the compounds are also disclosed.

L'invention concerne des composés qui sont des formes modifiées d'agents thérapeutiques. Un composé de promédicament typique décrit dans cette invention comprend un agent thérapeutique, un oligopeptide présentant un reste d'isoleucine, un groupe stabilisant, et éventuellement, un groupe de liaison. Le promédicament peut être clivé par une enzyme associée à une cellule cible. L'invention concerne également des méthodes de fabrication et d'utilisation de ces composés.

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