C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/4025 (2006.01) A61P 25/28 (2006.01) C07D 207/12 (2006.01) C07D 477/02 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2379972
This invention described an ICE inhibitor prodrug (I) having good bioavailability. Compound of formula (I) is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, inflammatory peritonitis, septic shock, pancreatitis, traumatic brain injury, organ transplant rejection, osteoarthritis, asthama, psoriasis, Alzheimer's disease, myocardial infarction, congestive heart failure, Huntington's disease, atherosclerosis, atopic dermatitis, leukemias and related disorders, myelodysplastic syndrome, uveitis or multiple myeloma.
L'invention concerne un promédicament inhibiteur d'ICE (I) à bonne biodisponibilité. Le composé de formule (I) est utile pour le traitement des maladies dont la médiation est assurée par l'IL-1, du type polyarthrite rhumatoïde, affection intestinale inflammatoire, maladie de Crohn, colite ulcéreuse, péritonite inflammatoire, choc spetique, pancréatite, traumatisme cérébral, rejet de greffe d'organe, ostéoarthrite, asthme, psoriasis, maladie d'Alzheimer, infarctus du myocarde, insuffisance cardiaque globale, maladie de Huntington, athérosclerose, dermatite atopique, leucémies et troubles connexes, syndrome myélodysplasique, uvéite ou myélome multiple.
Davies Robert
Wannamaker Marion
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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