Prodrugs activated by rna-dependent dna-polymerases

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/7125 (2006.01) A61K 31/663 (2006.01) A61K 31/7115 (2006.01) A61K 47/34 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2575520

Herein described are prodrugs activated by RNA-dependent DNA-polymerases, such as telomerase and retroviral reverse transcriptases, their use for the treatment of haematological tumours and of blood and blood derivatives from patients affected by retroviral infections, and their use for the preparation of pharmaceutical compositions, to be used for the treatment of solid tumours, of precancerous states and of diseases caused by infection with retroviruses.

L'invention concerne des promédicaments activés par des polymérases d'ADN dépendantes de l'ARN, telles que la télomérase et les transcriptases inverses rétrovirales, l'utilisation de ceux-ci dans le traitement de tumeurs hématologiques et du sang et de dérivés du sang prélevé chez des patients souffrant d'infections rétrovirales et l'utilisation de ceux-ci dans la préparation de compositions pharmaceutiques à utiliser dans le traitement de tumeurs solides, d'états précancéreux et de maladies engendrées par l'infection par des rétrovirus.

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