Prodrugs activated by targeted catalytic proteins

Details Prodrugs activated by targeted catalytic proteins Prodrugs activated by targeted catalytic proteins

C - Chemistry, Metallurgy

07

H

C07H 15/252 (2006.01) A61K 47/48 (2006.01) C07C 235/44 (2006.01) C07C 311/19 (2006.01) C07F 9/24 (2006.01) C07F 9/40 (2006.01) C07F 9/6509 (2006.01) C07F 9/6571 (2006.01) C07H 19/04 (2006.01) C07H 19/067 (2006.01) C07K 2/00 (2006.01) C07K 16/44 (2006.01) C07K 16/46 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2114934

2114934 9302703 PCTABS00019 Disclosed and claimed are prodrugs activated by catalytic proteins, such as enzymes and catalytic antibodies. The invention comprehends such prodrugs, as well as haptens, to elicit catalytic antibodies to activate the prodrugs. The prodrugs are useful as cytotoxic chemotherapeutic agents, e.g., as antitumor agents.

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