Prodrugs built as multiple self-elimination-release spacers

Details Prodrugs built as multiple self-elimination-release spacers Prodrugs built as multiple self-elimination-release spacers

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2506080

This invention concerns multiple release spacers and spacer systems, which release multiple leaving groups following a single activation. It concerns compounds comprising a specifier linked to two or more of the same or different leaving groups (L in the figure) via a self-eliminating multiple release spacer or spacer system, which compounds upon a single activation step, in particular removal or transformation of the specifier, release at least two leaving groups-.

L'invention concerne des espaceurs et des système d'espaceurs de libération multiple, libérant plusieurs groupes partants à la suite d'une activation simple. L'invention concerne notamment des composés comportant un spécificateur lié à au moins deux groupes partants identiques ou différents (L) par l'intermédiaire d'un espaceur ou d'un système d'espaceurs de libération multiple à élimination automatique. Lesdits composés libèrent au moins deux groupes partants en cas d'activation simple, en particulier en cas de retrait ou de transformation du spécificateur.

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