Prodrugs containing novel bio-cleavable linkers

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 323/12 (2006.01) A61K 47/48 (2006.01) C07C 321/14 (2006.01) C07C 323/23 (2006.01) C07D 207/46 (2006.01) C07D 309/12 (2006.01)

Patent

CA 2577490

The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula (I) or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula (I).

L'invention concerne des composés de formule (I) y compris leurs sels pharmaceutiquement acceptables, ainsi que des compositions pharmaceutiques renfermant ou plusieurs composés de formule (I) y compris leurs des intermédiaires correspondants et un ou plusieurs vecteurs, véhicules ou diluants pharmaceutiquement acceptables. On décrit aussi des procédés d'élaboration et d'utilisation des promédicaments y compris des promédicaments à libération de NO, des promédicaments doubles et des promédicaments mutuels renfermant les composés de formule (I).

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