Prodrugs for improved bioavailability of certain...

Details Prodrugs for improved bioavailability of certain... Prodrugs for improved bioavailability of certain...

C - Chemistry, Metallurgy

07

J

260/18

C07J 43/00 (2006.01) A61K 31/58 (2006.01)

Patent

CA 1148533

ABSTRACT OF THE DISCLOSURE Transient, orally active thiazolidine type prodrug forms of conventional, natural and synthetic ketosteroidal sex hormones, e.g., of progesterone, testosterone, and the like, are disclosed. The subject compounds can be prepared by known methods, for example, by reacting the corresponding 3-keto or 3,20-diketo steroids with a thiazolidine- forming reagent such as an L-cysteine alkyl ester.

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