C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/24 (2006.01) A61K 31/7064 (2006.01) A61P 31/14 (2006.01) A61P 35/00 (2006.01) C07H 19/02 (2006.01)
Patent
CA 2655904
The invention is directed to 5-amino-3-(3'-deoxy-.beta.-D-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione prodrugs, whose metabolized parent compound has immunomodulatory activity. The invention also relates to the therapeutic use of such prodrugs and pharmaceutical compositions thereof in treating disease states associated with abnormal cell growth, such as cancer.
La présente invention concerne des promédicaments de la 5-amino-3-(3'-désoxy-ß-D-ribofurannosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione, dont le composé parent métabolisé présente une activité immunomodulatrice. La présente invention concerne également l'emploi thérapeutique de tels promédicaments et des compositions pharmaceutiques les incluant dans le traitement d'états pathologiques associés à une croissance cellulaire anormale, par exemple les cancers.
Haley Gregory J.
Lennox Joseph R.
Webber Stephen E.
Xiang Alan Xin
Anadys Pharmaceuticals Inc.
Smart & Biggar
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