Prodrugs of 2-amino-6- ( { [2- (4-chlorphenyl) -1,...

Details Prodrugs of 2-amino-6- ( { [2- (4-chlorphenyl) -1,... Prodrugs of 2-amino-6- ( { [2- (4-chlorphenyl) -1,...

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/4418 (2006.01) A61P 9/00 (2006.01) A61P 11/06 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2698170

The present application relates to prodrug derivatives of 2-amino-6-({[2-(4- chlorophenyl)-1, 3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5- dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.

La présente invention concerne des dérivés prodrogues de 2-amino-6-({[2-(4-chlorophényl)-1,3- thiazol-4-yl]méthyl}thio)-4-[4-(2-hydroxyéthoxy)phényl]pyridine-3,5-dicarbonitrile, des procédés pour les préparer, leur utilisation pour le traitement et/ou la prévention de maladies, ainsi que leur utilisation pour préparer des médicaments destinés au traitement et/ou à la prévention de maladies, en particulier d'affections cardio-vasculaires.

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