C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/207, 167/254
C07C 233/00 (2006.01) A61K 31/24 (2006.01) C07C 233/36 (2006.01) C07C 275/14 (2006.01) C07D 307/24 (2006.01)
Patent
CA 2005373
-19- TITLE PRODRUGS OF 3,4-HYDROXY BENZOYLOXYPROPANOLAMINES ABSTRACT OF THE DISCLOSURE In accordance with the present invention, disclosed herein are compounds of the formula Image wherein R is straight or branched loweralkyl, R1 is hydrogen, straight or branched loweralkyl, lowercycloalkyl, amino, loweralkoxy or acylamino, and R2 is straight or branched loweralkyl, amino, cyclohexyl, morpholino, piperidino, tetrahydrofuranyl, dihydrofuranyl, tetrahydropyranyl, dioxolanyl, 2,2-dimethyl dioxolanyl, dioxanyl, pyrrolidinyl, tetra- hydrooxazolyl, and dihydrooxazolyl, and pharmaceutically acceptable salts thereof. The compounds are useful in the treatment of glaucoma.
Mai Khuong H.x.
Matier William L.
Patil Ghanshyam
Mai Khuong H.x.
Matier William L.
Patil Ghanshyam
Sim & Mcburney
The Du Pont Merck Pharmaceutical Company
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