Prodrugs of a 7-acylamino-3-heteroarylthio-3-cephem...

Details Prodrugs of a 7-acylamino-3-heteroarylthio-3-cephem... Prodrugs of a 7-acylamino-3-heteroarylthio-3-cephem...

C - Chemistry, Metallurgy

07

D

C07D 501/59 (2006.01) A61K 31/546 (2006.01) A61P 31/04 (2006.01) C07D 501/00 (2006.01)

Patent

CA 2423334

The present invention relates to prodrugs of the antibiotic compound (7R)-7- [(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(hydroxylimino)acetamido]acetamidol]-3- {3-(2-aminoethylthiomethyl]-pyrid-4-ylthio}-3-cephem-4-carbocyllic acid, where the prodrugs are substantially more water soluble at or near neutral pH than the parent compound.

La présente invention concerne des promédicaments du composé antibiotique acide (7R)-7-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(hydroxylimino)acétamido]acétamidol]-3-{3-(2-aminoéthylthiométhyl]-pyrid-4-ylthio}-3-céphème-4- carboxylique, les promédicaments étant sensiblement plus solubles dans une eau à pH neutre ou proche d'un pH neutre que le composé d'origine.

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