Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

Details Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

C - Chemistry, Metallurgy

07

D

167/240, 260/207

C07D 209/34 (2006.01) A61K 31/40 (2006.01) C07D 409/04 (2006.01) C07D 409/06 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 1339558

Certain enol ethers and esters of the formula Image where X and Y are each hydrogen, fluoro or chloro: R1 is 2-thienyl or benzyl and R is alkanoyl, cycloalkylcarbonyl, benzoyl, phenylalkanoyl, chlorobenzoyl, methoxybenzyl, phenyl, thenoyl, omega-alkoxycarbonylalkanoyl, alkoxycarbonyl, phenoxycarbonyl, 1-alkoxyalkyl, 1-alkoxycarbonyloxyalkyl, alkyl, alkylsulfonyl, methylphenylsulfonyl or dialkylphosphonate are useful as prodrug forms the known 3-acyl-2-oxindole-1-carboxamide anti-inflammatory and analgesic agents.

614317

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