Prodrugs of aspartyl protease inhibitors

Details Prodrugs of aspartyl protease inhibitors Prodrugs of aspartyl protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 307/20 (2006.01) A61K 31/18 (2006.01) A61K 31/27 (2006.01) A61K 31/34 (2006.01) A61K 31/4025 (2006.01) A61K 31/496 (2006.01) A61K 31/665 (2006.01) A61K 31/7048 (2006.01) A61P 31/18 (2006.01) C07C 311/18 (2006.01) C07C 311/19 (2006.01) C07D 207/14 (2006.01) C07D 217/26 (2006.01) C07D 241/04 (2006.01) C07D 243/04 (2006.01) C07D 277/30 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01) C07F 9/655 (2006.01) C07F 9/6584 (2006.01) C07H 15/0

Patent

CA 2231700

The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solubility, high oral bioavailability and facile in vivo generation of the active ingredient. This invention also relates to pharmaceutical compositions comprising these prodrugs. The prodrugs and pharmaceutical compositions of this invention are particularly well suited for decreasing the pill burden and increasing patient compliance. This invention also relates to methods of treating mammals with these prodrugs and pharmaceutical compositions.

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